1. RECIST - Definitions
2. Measure the longest in plane diameter
3. Target Measurement Rules
4. Selecting Target Lesions
5. Importance of Imaging Consistency
6. Importance of IV-Contrast
7. Importance of i.v.-contrast and proper timing, scanning delay
8. Imaging: Anatomy for CT/MRI
9. Target Measurement Rules at Follow-up
10. Progression by Non-Targets only
11. Reappearing Lesion
12. Splitting Lesions
13. Merging Lesions
14. Merging lesions example
15. Variable Enhancement
16. Lung Lesion develops cavity
17. Lymph Node Measurements, CT
18. Lymph Node Measurements, MRI
19. Bone mets
20. MRI
21. PET
22. Overview: RECIST vs. RECIST 1.1

It is sometimes reasonable to incorporate FDG-PET to complement CT scanning in assessment of progression

Negative PET at baseline, with a positive PET at follow-up is PD based on a new lesion. No PET at baseline and a positive PET at follow-up: If the positive PET at follow-up corresponds to a new site of disease on CT, this is PD. If the positive PET at follow-up is not confirmed as a new site of disease on CT, additional follow-up CT scans are needed to determine if there is truly progression occurring at that site (if so, the date of PD will be the date of the initial abnormal PET scan). If the positive PET at follow-up corresponds to a pre-existing site of disease on CT that is not progressing on the basis of the anatomic images, this is not PD.