Topic 5 | Section 3.1.3

Change 5: Cystic Lesions


  • Lesions considered to be truly non-measurable include the following: bone lesions, leptomeningeal disease, ascites, pleural/pericardial effusion, inflammatory breast disease, lymphangitis cutis/pulmonis, abdominal masses that are not confirmed and followed by imaging techniques, and cystic lesions.


  • Lesions that meet radiographic criteria for simple cysts should not be considered as malignant lesions (neither measurable nor non-measurable)
  • Radiographically indeterminate, complex "cystic" lesions should be considered non-measurable lesions
  • "Cystic Lesions" thought to be cystic metastases can be considered as measurable lesions, if they meet the definition of measurability. However, if non-cystic lesions are present in the same patient, these should be preferably selected for assessment.
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